HCR Update from Mark Sanna: Drinking just four glasses of wine for women or five glasses for men in 2 hours - the official definition of binge drinking - may do more harm to a person's health than previously thought, according to new research. Dr. Gyongyi Szabo and colleagues from the University of Massachusetts Medical School in Worcester report their findings in the journal PLOS ONE. They found even a single alcohol binge drinking episode increases toxins in the blood - due to bacteria leaking from the gut - to levels that can trigger immune cells involved in fever, inflammation and tissue destruction.